Reactome | Hh-Npp binds BOC:PTCH1

Schema > Reaction > Entries

Hh-Npp binds BOC:PTCH1 Show undefined attributes

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5632655] Rothfels, Karen, 2014-10-28
dbId	5632653
displayName	Hh-Npp binds BOC:PTCH1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632681] Ligand-receptor interactions - Homo sapiens
inferredFrom	[Reaction:R-MMU-5632654] Shh binds Boc:Ptch1 - Mus musculus
input	[Complex:R-HSA-5632584] BOC:PTCH1 [ciliary membrane] [CandidateSet:R-HSA-5362783] Hh-Npp [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:208047] Dual roles for patched in sequestering and transducing Hedgehog [LiteratureReference:208217] Biochemical evidence that patched is the Hedgehog receptor [LiteratureReference:208237] The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-Npp binds BOC:PTCH1
output	[Complex:R-HSA-5632588] Hh-Npp:BOC:PTCH1 [ciliary membrane]
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5632653
summation	[Summation:5632424] Hh pathway activation depends upon the binding of Hh ligand ...

Referrals

(hasEvent)	[Pathway:R-HSA-5632681] Ligand-receptor interactions
(inferredTo)	[Reaction:R-MMU-5632654] Shh binds Boc:Ptch1