Reactome | Hh-Npp binds GAS1 and PTCH

Schema > Reaction > Entries

Hh-Npp binds GAS1 and PTCH Show undefined attributes

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5632650] Rothfels, Karen, 2014-10-28
dbId	5632649
displayName	Hh-Npp binds GAS1 and PTCH
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632681] Ligand-receptor interactions - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-449167] GAS1 [plasma membrane] [CandidateSet:R-HSA-5362783] Hh-Npp [extracellular region] [EntityWithAccessionedSequence:R-HSA-5610415] PTCH1 [ciliary membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5629114] Gas1 extends the range of Hedgehog action by facilitating its signaling [LiteratureReference:5629141] The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629121] Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH [LiteratureReference:5629135] The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Hh-Npp binds GAS1 and PTCH
orthologousEvent	[Reaction:R-XTR-5632649] Hh-Npp binds GAS1 and PTCH - Xenopus tropicalis [Reaction:R-SSC-5632649] Hh-Npp binds GAS1 and PTCH - Sus scrofa [Reaction:R-BTA-5632649] Hh-Npp binds GAS1 and PTCH - Bos taurus [Reaction:R-CFA-5632649] Hh-Npp binds GAS1 and PTCH - Canis familiaris [Reaction:R-MMU-5632649] Hh-Npp binds GAS1 and PTCH - Mus musculus
output	[Complex:R-HSA-5632592] Hh-Npp:GAS1:PTCH [ciliary membrane]
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5632649
summation	[Summation:5632423] GAS1 is a vertebrate-specific Hh coreceptor that binds direc...

Referrals

(hasEvent)

[Pathway:R-HSA-5632681] Ligand-receptor interactions