SESN1,2,3 bind AMPK

Stable Identifier
R-HSA-5631941
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SESN1,2,3 bind AMPK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).

Literature References
PubMed ID Title Journal Year
24366874 p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

Cam, M, Bid, HK, Xiao, L, Zambetti, GP, Houghton, PJ, Cam, H

J. Biol. Chem. 2014
22363791 Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells

Sanli, T, Linher-Melville, K, Tsakiridis, T, Singh, G

PLoS ONE 2012
18692468 p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

Budanov, AV, Karin, M

Cell 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
SESN1,2,3 bind AMPK (Bos taurus)
SESN1,2,3 bind AMPK (Caenorhabditis elegans)
SESN1,2,3 bind AMPK (Canis familiaris)
SESN1,2,3 bind AMPK (Danio rerio)
SESN1,2,3 bind AMPK (Dictyostelium discoideum)
SESN1,2,3 bind AMPK (Drosophila melanogaster)
SESN1,2,3 bind AMPK (Gallus gallus)
SESN1,2,3 bind AMPK (Mus musculus)
SESN1,2,3 bind AMPK (Rattus norvegicus)
SESN1,2,3 bind AMPK (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Wang, PY  (2014-12-30)
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-27)