SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).
Tsakiridis, T, Linher-Melville, K, Singh, G, Sanli, T
Zambetti, GP, Houghton, PJ, Bid, HK, Cam, H, Xiao, L, Cam, M
Budanov, AV, Karin, M
© 2023 Reactome