SESN1,2,3 bind AMPK

Stable Identifier
R-HSA-5631941
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).

Literature References
PubMed ID Title Journal Year
24366874 p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

Cam, M, Bid, HK, Xiao, L, Zambetti, GP, Houghton, PJ, Cam, H

J. Biol. Chem. 2014
22363791 Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells

Sanli, T, Linher-Melville, K, Tsakiridis, T, Singh, G

PLoS ONE 2012
18692468 p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

Budanov, AV, Karin, M

Cell 2008
Participants
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Created