Reactome | SESN1,2,3 bind AMPK

SESN1,2,3 bind AMPK

Stable Identifier

R-HSA-5631941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24366874	p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage Cam, M, Bid, HK, Xiao, L, Zambetti, GP, Houghton, PJ, Cam, H	J. Biol. Chem.	2014
22363791	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells Sanli, T, Linher-Melville, K, Tsakiridis, T, Singh, G	PLoS ONE	2012
18692468	p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling Budanov, AV, Karin, M	Cell	2008