SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).
Cam, M, Bid, HK, Xiao, L, Zambetti, GP, Houghton, PJ, Cam, H
Sanli, T, Linher-Melville, K, Tsakiridis, T, Singh, G
Budanov, AV, Karin, M
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