Reactome | p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein

Schema > Reaction > Entries

p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10401245
displayName	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
eventOf	[Pathway:R-BTA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Bos taurus
inferredFrom	[Reaction:R-HSA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Homo sapiens
input	[Complex:R-BTA-5618095] HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] 2 × [EntityWithAccessionedSequence:R-BTA-265269] PTGES3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
output	[Complex:R-BTA-5618079] HSP70:ATP [cytosol] [Complex:R-BTA-5618074] HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol] [EntityWithAccessionedSequence:R-BTA-443857] STIP1 [cytosol]
precedingEvent	[Reaction:R-BTA-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5618098
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-BTA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
(inferredTo)	[Reaction:R-HSA-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein

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