Reactome | Immunophilin p23 (also known as PTGES3) binds selectively to...

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created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
dbId	5618114
displayName	Immunophilin p23 (also known as PTGES3) binds selectively to...
literatureReference	[LiteratureReference:8944723] The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes [LiteratureReference:5324657] N-terminal domain of human Hsp90 triggers binding to the cochaperone p23 [LiteratureReference:5324669] The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
modified	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
schemaClass	Summation
text	Immunophilin p23 (also known as PTGES3) binds selectively to the ATP-bound state of HSP90. p23 stabilizes the closed state of HSP90, which weakens the binding of STIP1(HOP) and promotes its exit from the complex (McLaughlin H et al. 2006; Karag�z GE et al. 2011). When FKBP51 (FKBP5) is present, a stable intermediate FKBP51:GR:HSP90:p23 is formed by expulsion of HSP70 and STIP1(HOP) (Ebong I et al. 2016).

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