p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein

Stable Identifier
R-HSA-5618098
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Immunophilin p23 (also known as PTGES3) binds selectively to the ATP-bound state of HSP90. p23 stabilizes the closed state of HSP90, which weakens the binding of STIP1(HOP) and promotes its exit from the complex (McLaughlin H et al. 2006; Karagöz GE et al. 2011). When FKBP51 (FKBP5) is present, a stable intermediate FKBP51:GR:HSP90:p23 is formed by expulsion of HSP70 and STIP1(HOP) (Ebong I et al. 2016).

Literature References
PubMed ID Title Journal Year
21183720 N-terminal domain of human Hsp90 triggers binding to the cochaperone p23

Karagöz, GE, Duarte, AM, Ippel, H, Uetrecht, C, Sinnige, T, van Rosmalen, M, Hausmann, J, Heck, AJ, Boelens, R, Rüdiger, SG

Proc. Natl. Acad. Sci. U.S.A. 2011
16403413 The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

McLaughlin, SH, Sobott, F, Yao, ZP, Zhang, W, Nielsen, PR, Grossmann, JG, Laue, ED, Robinson, CV, Jackson, SE

J. Mol. Biol. 2006
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