p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein

Stable Identifier
Reaction [transition]
Homo sapiens
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Immunophilin p23 (also known as PTGES3) binds selectively to the ATP-bound state of HSP90. p23 stabilizes the closed state of HSP90, which weakens the binding of STIP1(HOP) and promotes its exit from the complex (McLaughlin H et al. 2006; Karagöz GE et al. 2011). When FKBP51 (FKBP5) is present, a stable intermediate FKBP51:GR:HSP90:p23 is formed by expulsion of HSP70 and STIP1(HOP) (Ebong I et al. 2016).

Literature References
PubMed ID Title Journal Year
16403413 The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

Yao, ZP, Nielsen, PR, Sobott, F, McLaughlin, SH, Robinson, CV, Laue, ED, Grossmann, JG, Zhang, W, Jackson, SE

J. Mol. Biol. 2006
21183720 N-terminal domain of human Hsp90 triggers binding to the cochaperone p23

Boelens, R, van Rosmalen, M, Uetrecht, C, Sinnige, T, Heck, AJ, Duarte, AM, Rüdiger, SG, Karagöz, GE, Ippel, H, Hausmann, J

Proc. Natl. Acad. Sci. U.S.A. 2011
Orthologous Events
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