Reactome | Retinoic acid activates Hoxa4 chromatin

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Retinoic acid activates Hoxa4 chromatin Show undefined attributes

authored	[InstanceEdit:5618010] May, Bruce, 2014-08-16 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5619416] May, Bruce, 2014-08-22
dbId	5619434
displayName	Retinoic acid activates Hoxa4 chromatin
edited	[InstanceEdit:5618010] May, Bruce, 2014-08-16
followingEvent	[BlackBoxEvent:R-MMU-5619414] Hoxa4 gene is transcribed - Mus musculus
input	[SimpleEntity:R-ALL-5334804] atRA [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556805] Ep300 [nucleoplasm] [Complex:R-MMU-5619354] Mll2,3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556815] Ncoa3 [nucleoplasm] [Complex:R-MMU-5619338] Rara,b:Rxra at Hoxa4 bivalent chromatin [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5619229] Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning [LiteratureReference:5619158] Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element [LiteratureReference:5619269] Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron [LiteratureReference:5619306] HOXD4 and regulation of the group 4 paralog genes [LiteratureReference:5621541] Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development [LiteratureReference:5617993] Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid [LiteratureReference:5626755] KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development [LiteratureReference:5618004] Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals [LiteratureReference:5617912] Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts [LiteratureReference:5617928] Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells [LiteratureReference:5690634] Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates Hoxa4 chromatin
orthologousEvent	[BlackBoxEvent:R-HSA-5617862] Retinoic acid activates HOXA4 chromatin - Homo sapiens
output	[Complex:R-MMU-5619385] atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-442459] Ncor1 [nucleoplasm] [Complex:R-MMU-5617945] PRC2 (EZH2) [nucleoplasm]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5619434
summation	[Summation:5621559] In mouse embryos retinoic acid initially activates expressio...

Referrals

(precedingEvent)

[BlackBoxEvent:R-MMU-5619414] Hoxa4 gene is transcribed

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