Reactome | GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

Schema > BlackBoxEvent > Entries

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP Show undefined attributes

catalystActivity	[CatalystActivity:10732838] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10790427
displayName	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
eventOf	[Pathway:R-GGA-5610780] Degradation of GLI1 by the proteasome - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Homo sapiens
input	[Complex:R-GGA-5610612] ub-pS-GLI1:SUFU [ciliary base]
isInDisease	false
isInferred	true
maxDepth	1
name	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
output	[EntityWithAccessionedSequence:R-GGA-445455] SUFU [cytosol]
precedingEvent	[Reaction:R-GGA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-5610758
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5610780] Degradation of GLI1 by the proteasome
(inferredTo)	[BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

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