Reactome | LIG1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

LIG1 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5690630] DNA ligase activity of LIG1 [nucleoplasm] [CatalystActivity:109965] DNA ligase activity of LIG1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5651810] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-110371] LIG1 binds APEX1 and PCNA at SSB - Homo sapiens [Reaction:R-HSA-5651773] LIG1 binds POLB at long-patch BER site - Homo sapiens [BlackBoxEvent:R-HSA-9980021] LIG1 binds SSA sites - Homo sapiens
dbId	53787
displayName	LIG1 [nucleoplasm]
endCoordinate	919
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-53787] LIG1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-53787] LIG1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-53787] LIG1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-53787] LIG1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-53787] LIG1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-53787] lig1 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-53787] lig1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-53787] LIG1 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-53787] DNAlig1 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-53787] LIG1 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-53787] LIG1 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-53787] LIG1 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-53787] LIG1 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-53787] LIG1 [nucleoplasm] - Plasmodium falciparum
isRequired	[Requirement:R-HSA-182796] Requirement by 'LIG1 [nucleoplasm]'
maxDepth	1
memberOf	[DefinedSet:R-HSA-5690475] LIG1,LIG3:XRCC1 [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	LIG1 DNA ligase I Polydeoxyribonucleotide synthase (ATP)
positivelyRegulates	[Requirement:R-HSA-182796] Requirement by 'LIG1 [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-5651792] LIG1 and POLB dissociate from repaired dsDNA - Homo sapiens [BlackBoxEvent:R-HSA-9858729] MITF-M-dependent LIG1 expression - Homo sapiens [Reaction:R-HSA-5651809] LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA - Homo sapiens [BlackBoxEvent:R-HSA-5686663] Completion of SSA - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P18858] UniProt:P18858 LIG1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-53787
startCoordinate	1
updateTrackers	[UpdateTracker:9879951] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v44:[modifyEndCoordinate] [UpdateTracker:9886845] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v45:[addName] [UpdateTracker:9871793] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v41:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9879951] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v44:[modifyEndCoordinate] [UpdateTracker:9886845] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v45:[addName] [UpdateTracker:9871793] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v41:[modifyName]
(activeUnit)	[CatalystActivity:5651803] DNA ligase activity of LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] [CatalystActivity:5651794] DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [CatalystActivity:9980014] DNA ligase activity of LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(output)	[Reaction:R-HSA-5651809] LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA [Reaction:R-HSA-5651792] LIG1 and POLB dissociate from repaired dsDNA [BlackBoxEvent:R-HSA-9858729] MITF-M-dependent LIG1 expression [BlackBoxEvent:R-HSA-5686663] Completion of SSA
(hasComponent)	[Complex:R-HSA-5651810] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] [Complex:R-HSA-5651808] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] [Complex:R-HSA-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [Complex:R-HSA-5651790] LIG1:POLB:dsDNA [nucleoplasm] [Complex:R-HSA-9980008] LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(input)	[Reaction:R-HSA-110371] LIG1 binds APEX1 and PCNA at SSB [Reaction:R-HSA-5651773] LIG1 binds POLB at long-patch BER site [BlackBoxEvent:R-HSA-9980021] LIG1 binds SSA sites
(regulator)	[Requirement:R-HSA-182796] Requirement by 'LIG1 [nucleoplasm]'
(physicalEntity)	[CatalystActivity:5690630] DNA ligase activity of LIG1 [nucleoplasm] [CatalystActivity:109965] DNA ligase activity of LIG1 [nucleoplasm]
(hasMember)	[DefinedSet:R-HSA-5690475] LIG1,LIG3:XRCC1 [nucleoplasm]

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