Reactome | LIG1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10997649] DNA ligase activity of LIG1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DDI-5651790] LIG1:POLB:dsDNA [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] - Dictyostelium discoideum
consumedByEvent	[Reaction:R-DDI-5651773] LIG1 binds POLB at long-patch BER site - Dictyostelium discoideum [BlackBoxEvent:R-DDI-9980021] LIG1 binds SSA sites - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	10997648
displayName	LIG1 [nucleoplasm]
endCoordinate	919
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-53787] LIG1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	LIG1 Q869E1
referenceEntity	[ReferenceGeneProduct:uniprot:Q869E1] UniProt:Q869E1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-53787
startCoordinate	1

(activeUnit)	[CatalystActivity:11025152] DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
(input)	[Reaction:R-DDI-5651773] LIG1 binds POLB at long-patch BER site [BlackBoxEvent:R-DDI-9980021] LIG1 binds SSA sites
(hasComponent)	[Complex:R-DDI-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [Complex:R-DDI-5651790] LIG1:POLB:dsDNA [nucleoplasm] [Complex:R-DDI-9980008] LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10997649] DNA ligase activity of LIG1 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-53787] LIG1 [nucleoplasm]

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