Reactome | LIG1 binds POLB at long-patch BER site

Schema > Reaction > Entries

LIG1 binds POLB at long-patch BER site Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651765] Orlic-Milacic, Marija, 2014-11-24
dbId	5651773
displayName	LIG1 binds POLB at long-patch BER site
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair - Homo sapiens
followingEvent	[Reaction:R-HSA-5651789] LIG1 bound to POLB ligates SSB - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-53787] LIG1 [nucleoplasm] [Complex:R-HSA-5651778] POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5651781] Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis [LiteratureReference:5651763] Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta [LiteratureReference:5651761] Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex [LiteratureReference:111254] AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. [LiteratureReference:5651775] Completion of base excision repair by mammalian DNA ligases
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	LIG1 binds POLB at long-patch BER site
orthologousEvent	[Reaction:R-SCE-5651773] LIG1 binds POLB at long-patch BER site - Saccharomyces cerevisiae [Reaction:R-DDI-5651773] LIG1 binds POLB at long-patch BER site - Dictyostelium discoideum [Reaction:R-GGA-5651773] LIG1 binds POLB at long-patch BER site - Gallus gallus [Reaction:R-XTR-5651773] LIG1 binds POLB at long-patch BER site - Xenopus tropicalis [Reaction:R-DRE-5651773] LIG1 binds POLB at long-patch BER site - Danio rerio [Reaction:R-SSC-5651773] LIG1 binds POLB at long-patch BER site - Sus scrofa [Reaction:R-BTA-5651773] LIG1 binds POLB at long-patch BER site - Bos taurus [Reaction:R-CFA-5651773] LIG1 binds POLB at long-patch BER site - Canis familiaris [Reaction:R-RNO-5651773] LIG1 binds POLB at long-patch BER site - Rattus norvegicus [Reaction:R-MMU-5651773] LIG1 binds POLB at long-patch BER site - Mus musculus
output	[Complex:R-HSA-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5651782] FEN1 bound to POLB cleaves displaced DNA strand (flap) - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5651773
summation	[Summation:5651780] DNA ligase I (LIG1) binds DNA polymerase beta (POLB) at the ...

Referrals

(hasEvent)	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-HSA-5651789] LIG1 bound to POLB ligates SSB