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Schema
>
Complex
>
Entries
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
Show undefined attributes
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catalystActivities
[CatalystActivity:5357871] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Homo sapiens
[Reaction:R-HSA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Homo sapiens
[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Homo sapiens
created
[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId
5357749
displayName
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
hasComponent
[Complex:R-HSA-5357865] LUBAC [cytosol]
[Complex:R-HSA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
inDisease
false
includedLocation
[Compartment:70101] cytosol
inferredTo
[Complex:R-MMU-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Mus musculus
[Complex:R-RNO-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Rattus norvegicus
[Complex:R-CFA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Canis familiaris
[Complex:R-BTA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Bos taurus
[Complex:R-SSC-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Sus scrofa
isChimeric
false
literatureReference
[LiteratureReference:5357863] Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
maxDepth
6
memberOf
[DefinedSet:R-HSA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] - Homo sapiens
modified
[InstanceEdit:5658063] Shamovsky, V, 2014-12-17
name
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC
producedByEvent
[Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-5357749
updateTrackers
[UpdateTracker:9904410] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v82:[updateContainedComponent]
[UpdateTracker:9928597] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v91:[updateContainedComponent]
[UpdateTracker:9903793] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v80:[updateContainedComponent]
[UpdateTracker:9894600] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v57:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9904410] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v82:[updateContainedComponent]
[UpdateTracker:9928597] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v91:[updateContainedComponent]
[UpdateTracker:9903793] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v80:[updateContainedComponent]
[UpdateTracker:9894600] Update Tracker - [Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - v57:[updateContainedComponent]
(hasComponent)
[Complex:R-HSA-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane]
[Complex:R-HSA-5357936] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane]
(input)
[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
[Reaction:R-HSA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627
(output)
[Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
(physicalEntity)
[CatalystActivity:5357871] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
(hasMember)
[DefinedSet:R-HSA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
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