Reactome | TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]

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TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10437242] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-BTA-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Bos taurus [Reaction:R-BTA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Bos taurus [BlackBoxEvent:R-BTA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10399285
displayName	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
hasComponent	[Complex:R-BTA-5357865] LUBAC [cytosol] [Complex:R-BTA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] - Homo sapiens
maxDepth	6
memberOf	[DefinedSet:R-BTA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] - Bos taurus
name	TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC
producedByEvent	[Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5357749
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-BTA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Reaction:R-BTA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG [BlackBoxEvent:R-BTA-9793679] LUBAC ubiquitinates RIPK1 at K627
(hasComponent)	[Complex:R-BTA-5357837] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] [Complex:R-BTA-5357936] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane]
(physicalEntity)	[CatalystActivity:10437242] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
(output)	[Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
(hasMember)	[DefinedSet:R-BTA-9793686] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
(inferredTo)	[Complex:R-HSA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]

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