Reactome | LUBAC [cytosol]

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LUBAC [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5661506] LUBAC:OTULIN [cytosol] - Homo sapiens [Complex:R-HSA-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol] - Homo sapiens [Complex:R-HSA-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5661517] LUBAC binds OTULIN - Homo sapiens [Reaction:R-HSA-9794008] LUBAC binds CFLAR - Homo sapiens [Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Homo sapiens [Reaction:R-HSA-9796691] SPATA2 links CYLD to LUBAC - Homo sapiens [Reaction:R-HSA-9796691] SPATA2 links CYLD to LUBAC - Homo sapiens
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357865
displayName	LUBAC [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-976018] RBCK1 [cytosol] [EntityWithAccessionedSequence:R-HSA-5212660] RNF31 [cytosol] [EntityWithAccessionedSequence:R-HSA-5212666] SHARPIN [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-5357865] LUBAC [cytosol] - Mus musculus [Complex:R-RNO-5357865] LUBAC [cytosol] - Rattus norvegicus [Complex:R-CFA-5357865] LUBAC [cytosol] - Canis familiaris [Complex:R-BTA-5357865] LUBAC [cytosol] - Bos taurus [Complex:R-SSC-5357865] LUBAC [cytosol] - Sus scrofa [Complex:R-DRE-5357865] LUBAC [cytosol] - Danio rerio
isChimeric	false
literatureReference	[LiteratureReference:5357868] A ubiquitin ligase complex assembles linear polyubiquitin chains [LiteratureReference:5357909] SHARPIN forms a linear ubiquitin ligase complex regulating NF-?B activity and apoptosis
maxDepth	2
modified	[InstanceEdit:5660776] Shamovsky, V, 2015-01-06
name	LUBAC
producedByEvent	[BlackBoxEvent:R-HSA-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5357865
systematicName	RBCK1:RNF31:SHARPIN

Referrals

(activeUnit)	[PositiveRegulation:9819128] Positive regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]' [CatalystActivity:9818835] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] [CatalystActivity:5357871] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
(hasComponent)	[Complex:R-HSA-5661506] LUBAC:OTULIN [cytosol] [Complex:R-HSA-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol] [Complex:R-HSA-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] [Complex:R-HSA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] [Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol]
(input)	[Reaction:R-HSA-5661517] LUBAC binds OTULIN [Reaction:R-HSA-9794008] LUBAC binds CFLAR [Reaction:R-HSA-9796691] SPATA2 links CYLD to LUBAC [Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
(output)	[BlackBoxEvent:R-HSA-9793988] LUBAC ubiquitinates CFLAR at K351, K353

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