Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
Show undefined attributes
Go to Details
authored
[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId
5357904
displayName
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
edited
[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf
[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Homo sapiens
followingEvent
[Reaction:R-HSA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Homo sapiens
[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Homo sapiens
[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Homo sapiens
input
[Complex:R-HSA-5357865] LUBAC [cytosol]
[Complex:R-HSA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5357863] Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
maxDepth
1
modified
[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
orthologousEvent
[Reaction:R-SSC-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Sus scrofa
[Reaction:R-BTA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Bos taurus
[Reaction:R-CFA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Canis familiaris
[Reaction:R-RNO-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Rattus norvegicus
[Reaction:R-MMU-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Mus musculus
output
[Complex:R-HSA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
precedingEvent
[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Homo sapiens
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5357904
summation
[Summation:5627000] Ubiquitinated TRAF2 and BIRC2/3 were reported to recruit an ...
systematicName
TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 binds LUBAC
updateTrackers
[UpdateTracker:9847022] Update Tracker - [Reaction:5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - v82:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9847022] Update Tracker - [Reaction:5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - v82:[modifyText]
(precedingEvent)
[Reaction:R-HSA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
[Reaction:R-HSA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
[BlackBoxEvent:R-HSA-9793679] LUBAC ubiquitinates RIPK1 at K627
(hasEvent)
[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text