Reactome | TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG

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TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG Show undefined attributes

authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357776
displayName	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf	[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Homo sapiens
input	[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol] [Complex:R-HSA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
orthologousEvent	[Reaction:R-SSC-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Sus scrofa [Reaction:R-BTA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Bos taurus [Reaction:R-CFA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Canis familiaris [Reaction:R-RNO-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Rattus norvegicus [Reaction:R-MMU-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Mus musculus
output	[Complex:R-HSA-5357936] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane]
precedingEvent	[Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5357766] Negative regulation by 'RIPK1 deubiquitinases [cytosol]' [NegativeRegulation:R-HSA-5634135] Negative regulation by 'RACK1 [cytosol]' [PositiveRegulation:9819128] Positive regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]' [NegativeRegulation:9820386] Negative regulation by 'TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]'
regulationReference	[RegulationReference:9642010] Negative regulation by 'GNB2L1 [cytosol]' RACK1 modulates NF-?B activation by interfering with the interaction between TRAF2 and the IKK complex [RegulationReference:9820390] Negative regulation by 'TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]' Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25 [InstanceEdit:9818965] Tu, Hailin, 2022-10-31 [InstanceEdit:9828415] Muniti?, Ivana, 2023-02-14 [InstanceEdit:9830259] Franjki?, Toni, 2023-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5357776
summation	[Summation:5357963] K63-polyubiquitinated RIPK1 binds to IKBKG (NEMO), resulting...
updateTrackers	[UpdateTracker:9783067] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v57:[modifyText] [UpdateTracker:9846768] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v84:[modifyText] [UpdateTracker:9846840] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v83:[addRegulator, modifyText]

Referrals

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[Pathway:R-HSA-5357956] TNFR1-induced NF-kappa-B signaling pathway

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