Reactome | RAC1 binds PAK1-3

Schema > Reaction > Entries

RAC1 binds PAK1-3 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5357434] Garapati, P V, 2014-03-21
dbId	5357483
displayName	RAC1 binds PAK1-3
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent	[Reaction:R-HSA-5357445] PAK1-3 dimer disassociates - Homo sapiens
input	2 × [Complex:R-HSA-5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane] [DefinedSet:R-HSA-399856] PAK1,2,3 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:442644] Structural requirements for PAK activation by Rac GTPases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RAC1 binds PAK1-3
negativePrecedingEvent	[NegativePrecedingEvent:9866000] Futile Cycle: PAK1-3 autophosphorylates
orthologousEvent	[Reaction:R-CEL-5357483] RAC1 binds PAK1-3 - Caenorhabditis elegans [Reaction:R-DME-5357483] RAC1 binds PAK1-3 - Drosophila melanogaster [Reaction:R-GGA-5357483] RAC1 binds PAK1-3 - Gallus gallus [Reaction:R-SSC-5357483] RAC1 binds PAK1-3 - Sus scrofa [Reaction:R-CFA-5357483] RAC1 binds PAK1-3 - Canis familiaris [Reaction:R-RNO-5357483] RAC1 binds PAK1-3 - Rattus norvegicus [Reaction:R-MMU-5357483] RAC1 binds PAK1-3 - Mus musculus
output	[Complex:R-HSA-5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5357483
summation	[Summation:5357490] Activated Rac1 binds to and stimulates the kinase activity o...

Referrals

(hasEvent)	[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
(precedingEvent)	[Reaction:R-HSA-5357445] PAK1-3 dimer disassociates