Reactome | RAC1 binds PAK1-3

Schema > Reaction > Entries

RAC1 binds PAK1-3 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10964988
displayName	RAC1 binds PAK1-3
eventOf	[Pathway:R-CEL-5218920] VEGFR2 mediated vascular permeability - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5357445] PAK1-3 dimer disassociates - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 - Homo sapiens
input	2 × [Complex:R-CEL-5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane] [DefinedSet:R-CEL-399856] PAK1,2,3 dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAC1 binds PAK1-3
output	[Complex:R-CEL-5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]
precedingEvent	[Reaction:R-CEL-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5357483
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-5218920] VEGFR2 mediated vascular permeability
(precedingEvent)	[Reaction:R-CEL-5357445] PAK1-3 dimer disassociates
(inferredTo)	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3