Reactome | VAV exchanges GTP for GDP on RAC1, activating it

Schema > Reaction > Entries

VAV exchanges GTP for GDP on RAC1, activating it Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:8951588] guanyl-nucleotide exchange factor activity of p-VAV family:PIP3:RAC1:GDP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5218840] Garapati, P V, 2013-12-19
dbId	5218850
displayName	VAV exchanges GTP for GDP on RAC1, activating it
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 - Homo sapiens [Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Homo sapiens [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-8951587] p-VAV family:PIP3:RAC1:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	VAV exchanges GTP for GDP on RAC1, activating it
orthologousEvent	[Reaction:R-CEL-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Caenorhabditis elegans [Reaction:R-DME-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Drosophila melanogaster [Reaction:R-GGA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Gallus gallus [Reaction:R-XTR-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Xenopus tropicalis [Reaction:R-SSC-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Sus scrofa [Reaction:R-BTA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Bos taurus [Reaction:R-CFA-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Canis familiaris [Reaction:R-RNO-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Rattus norvegicus [Reaction:R-MMU-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-8951586] p-VAV family:PIP3 binds RAC1:GDP - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5218850
summation	[Summation:5218482] Tyrosine-phosphorylated VAVs act as guanine nucleotide excha...

Referrals

(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 [Reaction:R-HSA-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 [Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)