Reactome | PAK1-3 dimer disassociates

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PAK1-3 dimer disassociates Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5357434] Garapati, P V, 2014-03-21
dbId	5357445
displayName	PAK1-3 dimer disassociates
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent	[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates - Homo sapiens
input	[Complex:R-HSA-5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PAK1-3 dimer disassociates
orthologousEvent	[Reaction:R-CEL-5357445] PAK1-3 dimer disassociates - Caenorhabditis elegans [Reaction:R-DME-5357445] PAK1-3 dimer disassociates - Drosophila melanogaster [Reaction:R-GGA-5357445] PAK1-3 dimer disassociates - Gallus gallus [Reaction:R-SSC-5357445] PAK1-3 dimer disassociates - Sus scrofa [Reaction:R-CFA-5357445] PAK1-3 dimer disassociates - Canis familiaris [Reaction:R-RNO-5357445] PAK1-3 dimer disassociates - Rattus norvegicus [Reaction:R-MMU-5357445] PAK1-3 dimer disassociates - Mus musculus
output	2 × [Complex:R-HSA-5357487] p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5357445
summation	[Summation:5357438] Binding of Rac1 increases p21 activated kinases 1-3 (PAK1-3)...

Referrals

(hasEvent)	[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
(precedingEvent)	[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates

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