Reactome | RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils

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RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5218889] Shamovsky, V, 2013-12-20
dbId	5218905
displayName	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9686345] SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer - Homo sapiens [Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL - Homo sapiens
input	[Complex:R-HSA-5218870] p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218869] The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis [LiteratureReference:9697395] The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
orthologousEvent	[Polymerisation:R-SSC-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Sus scrofa [Polymerisation:R-BTA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Bos taurus [Polymerisation:R-CFA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Canis familiaris [Polymerisation:R-RNO-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Rattus norvegicus [Polymerisation:R-MMU-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Mus musculus
output	[Polymer:R-HSA-5218908] p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
precedingEvent	[Reaction:R-HSA-5213464] RIPK1 is phosphorylated - Homo sapiens [Reaction:R-HSA-5213466] RIPK3 is phosphorylated - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-5218905
summation	[Summation:5357800] Structural studies showed that activation of RIPK3 by RIPK1 ...
systematicName	p-S-RIPK1:p-S199,227-RIPK3 oligomerizes

Referrals

(precedingEvent)	[Reaction:R-HSA-9686345] SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer [Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL
(hasEvent)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis

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