Reactome | RIPK1-mediated regulated necrosis

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RIPK1-mediated regulated necrosis Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
created	[InstanceEdit:5213467] Shamovsky, V, 2013-12-13
crossReference	[DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	5213460
diseasePathways	[Pathway:R-HSA-9693928] Defective RIPK1-mediated regulated necrosis - Homo sapiens
displayName	RIPK1-mediated regulated necrosis
doi	10.3180/R-HSA-5213460.2
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5218859] Regulated Necrosis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396762] necroptotic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5213462] RIPK3 binds RIPK1 - Homo sapiens [Reaction:R-HSA-5213464] RIPK1 is phosphorylated - Homo sapiens [Reaction:R-HSA-5213466] RIPK3 is phosphorylated - Homo sapiens [Polymerisation:R-HSA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Homo sapiens [Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL - Homo sapiens [Reaction:R-HSA-5218906] RIPK3 phosphorylates MLKL - Homo sapiens [Polymerisation:R-HSA-5357927] MLKL oligomerizes - Homo sapiens [Reaction:R-HSA-5620975] MLKL binds PIPs - Homo sapiens [Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-12-07
literatureReference	[LiteratureReference:5620972] Characterization of TNF-induced caspase-independent necroptosis [LiteratureReference:5620970] Regulated necrosis: the expanding network of non-apoptotic cell death pathways [LiteratureReference:9698655] The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)
maxDepth	4
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	RIPK1-mediated regulated necrosis
orthologousEvent	[Pathway:R-CFA-5213460] RIPK1-mediated regulated necrosis - Canis familiaris [Pathway:R-BTA-5213460] RIPK1-mediated regulated necrosis - Bos taurus [Pathway:R-SSC-5213460] RIPK1-mediated regulated necrosis - Sus scrofa [Pathway:R-DRE-5213460] RIPK1-mediated regulated necrosis - Danio rerio [Pathway:R-XTR-5213460] RIPK1-mediated regulated necrosis - Xenopus tropicalis [Pathway:R-GGA-5213460] RIPK1-mediated regulated necrosis - Gallus gallus [Pathway:R-DME-5213460] RIPK1-mediated regulated necrosis - Drosophila melanogaster [Pathway:R-CEL-5213460] RIPK1-mediated regulated necrosis - Caenorhabditis elegans [Pathway:R-DDI-5213460] RIPK1-mediated regulated necrosis - Dictyostelium discoideum [Pathway:R-PFA-5213460] RIPK1-mediated regulated necrosis - Plasmodium falciparum [Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis - Rattus norvegicus [Pathway:R-MMU-5213460] RIPK1-mediated regulated necrosis - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5213460
summation	[Summation:5364099] Receptor-interacting serine/threonine-kinase protein 1 (RIPK...
updateTrackers	[UpdateTracker:9776892] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v74:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776333] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v76:[updateIndirectRLE] [UpdateTracker:9776569] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v75:[updateIndirectRLE] [UpdateTracker:9784122] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v54:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9846901] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v83:[updateContainedPathway] [UpdateTracker:9776150] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v77:[updateContainedRLE] [UpdateTracker:9777028] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v73:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9847002] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v82:[modifyText, removeHasEvent, updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5218859] Regulated Necrosis
(normalPathway)	[Pathway:R-HSA-9693928] Defective RIPK1-mediated regulated necrosis
(updatedInstance)	[UpdateTracker:9776892] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v74:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776333] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v76:[updateIndirectRLE] [UpdateTracker:9776569] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v75:[updateIndirectRLE] [UpdateTracker:9784122] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v54:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9846901] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v83:[updateContainedPathway] [UpdateTracker:9776150] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v77:[updateContainedRLE] [UpdateTracker:9777028] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v73:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9847002] Update Tracker - [Pathway:5213460] RIPK1-mediated regulated necrosis - v82:[modifyText, removeHasEvent, updateContainedPathway, updateIndirectRLE]

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