RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils

Stable Identifier
R-HSA-5218905
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Structural studies showed that activation of RIPK3 by RIPK1 involves the formation of a functional hetero-oligomeric amyloidal signaling complex that mediated programmed necrosis (Li J et al. 2012). The RIP homotypic interaction motifs (RHIMs) of RIPK1 and RIPK3 were found to mediate the assembly of these heterodimeric filamentous structures (Li J et al. 2012). RIPK1 was reported to control RIPK3 oligomerization in both postive and negative manners (Orozco S et al. 2014).

Literature References
PubMed ID Title Journal Year
22817896 The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

Li, J, McQuade, T, Siemer, AB, Napetschnig, J, Moriwaki, K, Hsiao, YS, Damko, E, Moquin, D, Walz, T, McDermott, A, Chan, FK, Wu, H

Cell 2012
Participants
Participant Of
Orthologous Events
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Created