Reactome | RIPK3 is phosphorylated

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RIPK3 is phosphorylated Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
catalystActivity	[CatalystActivity:5218883] protein serine/threonine kinase activity of RIPK1:RIPK3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5213467] Shamovsky, V, 2013-12-13
dbId	5213466
displayName	RIPK3 is phosphorylated
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
followingEvent	[Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL - Homo sapiens [Polymerisation:R-HSA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5218868] p-S-RIPK1:RIPK3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5620996] Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation [LiteratureReference:5620995] Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	RIPK3 is phosphorylated
orthologousEvent	[Reaction:R-PFA-5213466] RIPK3 is phosphorylated - Plasmodium falciparum [Reaction:R-DDI-5213466] RIPK3 is phosphorylated - Dictyostelium discoideum [Reaction:R-SSC-5213466] RIPK3 is phosphorylated - Sus scrofa [Reaction:R-BTA-5213466] RIPK3 is phosphorylated - Bos taurus [Reaction:R-CFA-5213466] RIPK3 is phosphorylated - Canis familiaris [Reaction:R-RNO-5213466] RIPK3 is phosphorylated - Rattus norvegicus [Reaction:R-MMU-5213466] RIPK3 is phosphorylated - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5218870] p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
precedingEvent	[Reaction:R-HSA-5213462] RIPK3 binds RIPK1 - Homo sapiens
regulatedBy	[NegativeRegulation:9693970] Negative regulation by 'RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]'
regulationReference	[RegulationReference:9693975] Negative regulation by 'RIPK1:RIPK3:sorafenib [cytosol]' Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5213466
summation	[Summation:5357772] Necroptosis is a form of regulated necrotic cell death media...
systematicName	p-S-RIPK1:RIPK3 phosphorylates RIPK3 to p-S-RIPK1:p-S199,227-RIPK3
updateTrackers	[UpdateTracker:9776824] Update Tracker - [Reaction:5213466] RIPK3 is phosphorylated - v74:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776824] Update Tracker - [Reaction:5213466] RIPK3 is phosphorylated - v74:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis
(precedingEvent)	[Polymerisation:R-HSA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils [Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL