Reactome | RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils

Schema > Polymerisation > Entries

RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10175381
displayName	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
eventOf	[Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5218891] RIPK1:RIPK3 oligomer binds MLKL - Rattus norvegicus
inferredFrom	[Polymerisation:R-HSA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Homo sapiens
input	[Complex:R-RNO-5218870] p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
output	[Polymer:R-RNO-5218908] p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol]
precedingEvent	[Reaction:R-RNO-5213464] RIPK1 is phosphorylated - Rattus norvegicus [Reaction:R-RNO-5213466] RIPK3 is phosphorylated - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Polymerisation
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5218905
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis
(precedingEvent)	[Reaction:R-RNO-5218891] RIPK1:RIPK3 oligomer binds MLKL
(inferredTo)	[Polymerisation:R-HSA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils

Cite Us!