Reactome | RIPK3 is phosphorylated

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RIPK3 is phosphorylated Show undefined attributes

catalystActivity	[CatalystActivity:11117850] protein serine/threonine kinase activity of RIPK1:RIPK3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11117869
displayName	RIPK3 is phosphorylated
eventOf	[Pathway:R-PFA-5213460] RIPK1-mediated regulated necrosis - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Polymerisation:R-PFA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-5213466] RIPK3 is phosphorylated - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-PFA-5218868] p-S-RIPK1:RIPK3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RIPK3 is phosphorylated
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-PFA-5218870] p-S166-RIPK1:p-S199,227-RIPK3 [cytosol]
regulatedBy	[NegativeRegulation:11117855] Negative regulation by 'RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-5213466
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-5213460] RIPK1-mediated regulated necrosis
(precedingEvent)	[Polymerisation:R-PFA-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
(inferredTo)	[Reaction:R-HSA-5213466] RIPK3 is phosphorylated