Reactome | Negative regulation by 'RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[ChemicalDrug:R-ALL-9657029] sorafenib [cytosol]
created	[InstanceEdit:9693949] Shamovsky, Veronica, 2020-07-08
dbId	9693970
displayName	Negative regulation by 'RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]'
modified	[InstanceEdit:9694039] Shamovsky, Veronica, 2020-07-08
regulatedEntity	[Reaction:R-HSA-5213464] RIPK1 is phosphorylated - Homo sapiens [Reaction:R-HSA-5213466] RIPK3 is phosphorylated - Homo sapiens
regulator	[Complex:R-HSA-9693943] RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]
schemaClass	NegativeRegulation

(regulatedBy)	[Reaction:R-HSA-5213464] RIPK1 is phosphorylated [Reaction:R-HSA-5213466] RIPK3 is phosphorylated
(regulation)	[RegulationReference:9693975] Negative regulation by 'RIPK1:RIPK3:sorafenib [cytosol]' Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

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