Reactome | MLKL binds PIPs

Schema > Reaction > Entries

MLKL binds PIPs Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5620978] Shamovsky, V, 2014-08-28
dbId	5620975
displayName	MLKL binds PIPs
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
input	[Complex:R-HSA-5357794] p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] [DefinedSet:R-ALL-5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5620988] MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates [LiteratureReference:5357933] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [LiteratureReference:5620989] Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MLKL binds PIPs
orthologousEvent	[Reaction:R-DDI-5620975] MLKL binds PIPs - Dictyostelium discoideum [Reaction:R-SSC-5620975] MLKL binds PIPs - Sus scrofa [Reaction:R-BTA-5620975] MLKL binds PIPs - Bos taurus [Reaction:R-RNO-5620975] MLKL binds PIPs - Rattus norvegicus [Reaction:R-MMU-5620975] MLKL binds PIPs - Mus musculus
output	[Complex:R-HSA-5620984] RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane]
precedingEvent	[Polymerisation:R-HSA-5357927] MLKL oligomerizes - Homo sapiens
regulatedBy	[NegativeRegulation:9692657] Negative regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane]' [NegativeRegulation:9692656] Negative regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol]'
regulationReference	[RegulationReference:9692660] Negative regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:FLOT1:FLOT2 [plasma membrane]' Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis [RegulationReference:9692659] Negative regulation by 'p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol]' Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5620975
summation	[Summation:5621015] Activated by phosphorylation, mixed lineage kinase domain-li...
systematicName	p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer binds PIPs
updateTrackers	[UpdateTracker:9776699] Update Tracker - [Reaction:5620975] MLKL binds PIPs - v74:[addRegulator, modifyText] [UpdateTracker:9776244] Update Tracker - [Reaction:5620975] MLKL binds PIPs - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776699] Update Tracker - [Reaction:5620975] MLKL binds PIPs - v74:[addRegulator, modifyText] [UpdateTracker:9776244] Update Tracker - [Reaction:5620975] MLKL binds PIPs - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis

Cite Us!