Reactome | RIPK1-mediated regulated necrosis

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RIPK1-mediated regulated necrosis Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224569
displayName	RIPK1-mediated regulated necrosis
eventOf	[Pathway:R-RNO-5218859] Regulated Necrosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:396762] necroptotic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-5213464] RIPK1 is phosphorylated - Rattus norvegicus [Reaction:R-RNO-5213466] RIPK3 is phosphorylated - Rattus norvegicus [Polymerisation:R-RNO-5218905] RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils - Rattus norvegicus [Reaction:R-RNO-5218891] RIPK1:RIPK3 oligomer binds MLKL - Rattus norvegicus [Reaction:R-RNO-5218906] RIPK3 phosphorylates MLKL - Rattus norvegicus [Reaction:R-RNO-5620975] MLKL binds PIPs - Rattus norvegicus [Pathway:R-RNO-5675482] Regulation of necroptotic cell death - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	RIPK1-mediated regulated necrosis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5213460
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5218859] Regulated Necrosis
(inferredTo)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis

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