Reactome | RIPK3 phosphorylates MLKL

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RIPK3 phosphorylates MLKL Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
catalystActivity	[CatalystActivity:5218886] protein serine/threonine kinase activity of (RIPK1:RIPK3)oligomer:4xMLKL [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5218889] Shamovsky, V, 2013-12-20
dbId	5218906
displayName	RIPK3 phosphorylates MLKL
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9793451] MLKL binds ITCH - Homo sapiens [Polymerisation:R-HSA-5357927] MLKL oligomerizes - Homo sapiens
input	[Complex:R-HSA-5218909] (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] 8 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218888] Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase [LiteratureReference:5620989] Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RIPK3 phosphorylates MLKL
orthologousEvent	[Reaction:R-DDI-5218906] RIPK3 phosphorylates MLKL - Dictyostelium discoideum [Reaction:R-SSC-5218906] RIPK3 phosphorylates MLKL - Sus scrofa [Reaction:R-BTA-5218906] RIPK3 phosphorylates MLKL - Bos taurus [Reaction:R-RNO-5218906] RIPK3 phosphorylates MLKL - Rattus norvegicus [Reaction:R-MMU-5218906] RIPK3 phosphorylates MLKL - Mus musculus
output	[Complex:R-HSA-5218902] (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] 8 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5218891] RIPK1:RIPK3 oligomer binds MLKL - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5218906
summation	[Summation:5357947] Receptor-interacting serine/threonine-protein kinase 3 (RIPK...
systematicName	p-S-RIPK1:p-S199,227-RIPK3 oligomer phosphorylates 3xMLKL to p-S-RIPK1:p-S199,227-RIPK3 oligomer:3xp-T357,S358-MLKL
updateTrackers	[UpdateTracker:9776924] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v73:[modifyText] [UpdateTracker:9776804] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v74:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776924] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v73:[modifyText] [UpdateTracker:9776804] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v74:[modifyText]
(precedingEvent)	[Reaction:R-HSA-9793451] MLKL binds ITCH [Polymerisation:R-HSA-5357927] MLKL oligomerizes
(hasEvent)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis

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