Anthrax lef cleaves target cell MAP2K1 (MEK1)

Stable Identifier
R-HSA-5211340
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
ReviewStatus
5/5
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Anthrax lef cleaves target cell MAP2K1 (MEK1)
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lef (Anthrax LF, lethal factor), a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K1 (MEK1, mitogen activated protein kinase kinase 1) at the N-terminus. While the kinase domain of MAP2K1 is unaffected, an aminoterminal docking domain is disrupted by the cleavage and the protein fails to interact normally with substrates (Duesbery et al. 1998; Vitale et al. 1998).
Literature References
PubMed ID Title Journal Year
9563949 Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

Klimpel, KR, Leppla, SH, Webb, CP, Paull, KD, Ahn, NG, Gordon, VM, Vande Woude, GF, Copeland, TD, Oskarsson, MK, Duesbery, NS, Fukasawa, K

Science 1998
9703991 Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

Mock, M, Pellizzari, R, Napolitani, G, Montecucco, C, Recchi, C, Vitale, G

Biochem. Biophys. Res. Commun. 1998
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Leppla, SH, Arora, N

Mol. Microbiol. 1994
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Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-10)
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