Reactome | p62 links damaged mitochondria to LC3

Schema > Reaction > Entries

p62 links damaged mitochondria to LC3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10397599
displayName	p62 links damaged mitochondria to LC3
eventOf	[Pathway:R-BTA-5205685] PINK1-PRKN Mediated Mitophagy - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Bos taurus
inferredFrom	[Reaction:R-HSA-5205649] p62 links damaged mitochondria to LC3 - Homo sapiens
input	[Complex:R-BTA-5205659] K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] [DefinedSet:R-BTA-5205658] LC3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p62 links damaged mitochondria to LC3
output	[Complex:R-BTA-5205670] LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol]
precedingEvent	[Reaction:R-BTA-5205673] p62 binds ubiquitinated mitochondrial substrates - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5205649
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-BTA-5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex
(inferredTo)	[Reaction:R-HSA-5205649] p62 links damaged mitochondria to LC3

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