Reactome | FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

Schema > BlackBoxEvent > Entries

FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner Show undefined attributes

authored	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
category	omitted
compartment	[Compartment:20592] clathrin-coated endocytic vesicle [Compartment:876] plasma membrane
created	[InstanceEdit:5140746] Rothfels, K, 2013-11-15
dbId	5140747
displayName	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner
edited	[InstanceEdit:5144530] Matthews, L, 2013-11-15
eventOf	[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Homo sapiens
input	[Complex:R-HSA-5140740] WNT5A:FZDs/ROR [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5140719] Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells [LiteratureReference:5140720] Wnt5a regulates distinct signalling pathways by binding to Frizzled2
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner
orthologousEvent	[BlackBoxEvent:R-CEL-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Caenorhabditis elegans [BlackBoxEvent:R-DME-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Drosophila melanogaster [BlackBoxEvent:R-GGA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Gallus gallus [BlackBoxEvent:R-XTR-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Xenopus tropicalis [BlackBoxEvent:R-SSC-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Sus scrofa [BlackBoxEvent:R-BTA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Bos taurus [BlackBoxEvent:R-CFA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Canis familiaris [BlackBoxEvent:R-RNO-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Rattus norvegicus [BlackBoxEvent:R-MMU-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Mus musculus
output	[Complex:R-HSA-5140748] WNT5A:FZDs/ROR [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-5140741] WNT5A binds FZD and ROR receptors - Homo sapiens
regulatedBy	[Requirement:R-HSA-5140749] Requirement by 'clathrin:AP-2 [plasma membrane]'
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5140747
summation	[Summation:5140737] Stimulation of HEK293, HeLaS3 or KKLS gastric cancer cells w...

Referrals

(hasEvent)

[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2