Reactome | WNT5A binds FZD and ROR receptors

Schema > Reaction > Entries

WNT5A binds FZD and ROR receptors Show undefined attributes

authored	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5140742] Rothfels, K, 2013-11-15
dbId	5140741
displayName	WNT5A binds FZD and ROR receptors
edited	[InstanceEdit:5144530] Matthews, L, 2013-11-15
eventOf	[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Homo sapiens
input	[CandidateSet:R-HSA-5140732] FZD2/FZD5/ROR2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3238088] Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling [LiteratureReference:5140720] Wnt5a regulates distinct signalling pathways by binding to Frizzled2 [LiteratureReference:5140717] An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT5A binds FZD and ROR receptors
orthologousEvent	[Reaction:R-CEL-5140741] WNT5A binds FZD and ROR receptors - Caenorhabditis elegans [Reaction:R-DME-5140741] WNT5A binds FZD and ROR receptors - Drosophila melanogaster [Reaction:R-GGA-5140741] WNT5A binds FZD and ROR receptors - Gallus gallus [Reaction:R-XTR-5140741] WNT5A binds FZD and ROR receptors - Xenopus tropicalis [Reaction:R-DRE-5140741] WNT5A binds FZD and ROR receptors - Danio rerio [Reaction:R-SSC-5140741] WNT5A binds FZD and ROR receptors - Sus scrofa [Reaction:R-BTA-5140741] WNT5A binds FZD and ROR receptors - Bos taurus [Reaction:R-CFA-5140741] WNT5A binds FZD and ROR receptors - Canis familiaris [Reaction:R-RNO-5140741] WNT5A binds FZD and ROR receptors - Rattus norvegicus [Reaction:R-MMU-5140741] WNT5A binds FZD and ROR receptors - Mus musculus
output	[Complex:R-HSA-5140740] WNT5A:FZDs/ROR [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5140741
summation	[Summation:5140738] WNT5A induces the internalization of FZD2, FZD5 and ROR2 in ...

Referrals

(hasEvent)	[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2
(precedingEvent)	[BlackBoxEvent:R-HSA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner