Reactome | WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Stable Identifier

R-HSA-5140745

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, clathrin-coated endocytic vesicle, cytosol, extracellular region

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WNT5A-dependent internalization of FZD2, FZD5 and ROR2

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Internalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2010; Hanaki et al, 2012; Yamamoto et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
17117926	Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling Kurayoshi, M, Yamamoto, H, Izumi, S, Kikuchi, A	Biochem. J.	2007
19910923	Wnt5a regulates distinct signalling pathways by binding to Frizzled2 Sato, A, Yamamoto, H, Sakane, H, Koyama, H, Kikuchi, A	EMBO J.	2010
22101459	An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis Hanaki, H, Yamamoto, H, Sakane, H, Matsumoto, S, Ohdan, H, Sato, A, Kikuchi, A	Mol. Cancer Ther.	2012
19582886	Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells Yamamoto, H, Yamamoto, H, Kitadai, Y, Oue, N, Ohdan, H, Yasui, W, Kikuchi, A	Gastroenterology	2009