Reactome | WNT5A-dependent internalization of FZD2, FZD5 and ROR2

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WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:20592] clathrin-coated endocytic vesicle [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730698
displayName	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
eventOf	[Pathway:R-XTR-4086400] PCP/CE pathway - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-5140741] WNT5A binds FZD and ROR receptors - Xenopus tropicalis [BlackBoxEvent:R-XTR-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5140745
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-4086400] PCP/CE pathway
(inferredTo)	[Pathway:R-HSA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2

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