Reactome | Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3

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Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:937003] MAP kinase kinase kinase kinase activity of p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:936995] Shamovsky, V, 2010-08-25
dbId	936991
displayName	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex - Homo sapiens
followingEvent	[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens [Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Homo sapiens [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo [LiteratureReference:169931] TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction [LiteratureReference:2586644] Structural basis for the interaction of TAK1 kinase with its activating protein TAB1 [LiteratureReference:2586636] Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 [LiteratureReference:2586622] An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
orthologousEvent	[Reaction:R-GGA-451447] Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 - Gallus gallus [Reaction:R-GGA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Gallus gallus [Reaction:R-XTR-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Xenopus tropicalis [Reaction:R-DRE-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Danio rerio [Reaction:R-SSC-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Sus scrofa [Reaction:R-BTA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Bos taurus [Reaction:R-CFA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Canis familiaris [Reaction:R-RNO-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Rattus norvegicus [Reaction:R-MMU-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Mus musculus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936991
summation	[Summation:450184] The TAK1 complex consists of Transforming growth factor-beta...
updateTrackers	[UpdateTracker:9788132] Update Tracker - [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - v43:[addLiteratureReference, modifyText] [UpdateTracker:9782389] Update Tracker - [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788132] Update Tracker - [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - v43:[addLiteratureReference, modifyText] [UpdateTracker:9782389] Update Tracker - [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex
(precedingEvent)	[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 [Reaction:R-HSA-450337] Activated TAK1 phosphorylates MKK4/MKK7 [Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex

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