Reactome | Active p38 MAPK phosphorylates MAPKAPK2 or 3

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Active p38 MAPK phosphorylates MAPKAPK2 or 3 Show undefined attributes

authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:442864] protein serine/threonine/tyrosine kinase activity of phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
dbId	442913
displayName	Active p38 MAPK phosphorylates MAPKAPK2 or 3
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation - Gallus gallus
followingEvent	[Reaction:R-GGA-442862] Nuclear export of p38 MAPK mediated by its substrate MAPKAPK2 or 3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-442905] phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:187736] Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2 [LiteratureReference:442952] Molecular basis of MAPK-activated protein kinase 2:p38 assembly [LiteratureReference:442929] Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer [LiteratureReference:442930] Catalysis and function of the p38 alpha.MK2a signaling complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active p38 MAPK phosphorylates MAPKAPK2 or 3
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-442915] phospho -p38 MAPK : phospho- MAPKAPK 2 or phospho MAPKAPK3 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus
regulatedBy	[NegativeRegulation:R-GGA-442897] Negative regulation by 'MAPK phosphatases [nucleoplasm]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-442913
summation	[Summation:444067] Human p38 MAPK alpha forms a complex with MK2 even when the ...
updateTrackers	[UpdateTracker:9787008] Update Tracker - [Reaction:442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787008] Update Tracker - [Reaction:442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[modifyText]
(precedingEvent)	[Reaction:R-GGA-442862] Nuclear export of p38 MAPK mediated by its substrate MAPKAPK2 or 3
(hasEvent)	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation
(inferredTo)	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3

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