Reactome | Active p38 MAPK phosphorylates MAPKAPK2 or 3

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Active p38 MAPK phosphorylates MAPKAPK2 or 3 Show undefined attributes

catalystActivity	[CatalystActivity:11114371] protein serine/threonine kinase activity of p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11114373
displayName	Active p38 MAPK phosphorylates MAPKAPK2 or 3
eventOf	[Pathway:R-PFA-2559580] Oxidative Stress Induced Senescence - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-PFA-450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Active p38 MAPK phosphorylates MAPKAPK2 or 3
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-PFA-450254] p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-450222
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-2559580] Oxidative Stress Induced Senescence [Pathway:R-PFA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)	[Reaction:R-PFA-450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
(inferredTo)	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3

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