Reactome | ZIP8 mediates zinc influx into cells

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ZIP8 mediates zinc influx into cells Show undefined attributes

authored	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity	[CatalystActivity:442423] zinc ion transmembrane transporter activity of SLC39A8-like proteins [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
crossReference	[DatabaseIdentifier:12667917] RHEA:62252 [DatabaseIdentifier:9958442] RHEA:62253
dbId	442387
displayName	ZIP8 mediates zinc influx into cells
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-442380] Zinc influx into cells by the SLC39 gene family - Homo sapiens
followingEvent	[Reaction:R-HSA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Homo sapiens [Reaction:R-HSA-437084] ZnT3 transports zinc into synaptic vesicles - Homo sapiens [Reaction:R-HSA-435375] ZnT2 facilitates zinc vesicular sequestration - Homo sapiens [Reaction:R-HSA-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule - Homo sapiens [Reaction:R-HSA-437139] ZnT8 transports zinc into the Golgi apparatus - Homo sapiens [Reaction:R-HSA-9820566] ZnT5 transports zinc into the golgi apparatus - Homo sapiens [Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Homo sapiens
input	2 × [SimpleEntity:R-ALL-425425] HCO3- [extracellular region] [SimpleEntity:R-ALL-158417] Zn2+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:445734] Discovery of ZIP transporters that participate in cadmium damage to testis and kidney [LiteratureReference:446537] The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia [LiteratureReference:3004709] ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ZIP8 mediates zinc influx into cells
negativePrecedingEvent	[NegativePrecedingEvent:9963152] Futile Cycle: ZnT1 mediates the efflux of zinc from the cell
orthologousEvent	[Reaction:R-CEL-442387] ZIP8 mediates zinc influx into cells - Caenorhabditis elegans [Reaction:R-DME-442387] ZIP8 mediates zinc influx into cells - Drosophila melanogaster [Reaction:R-GGA-442387] ZIP8 mediates zinc influx into cells - Gallus gallus [Reaction:R-XTR-442387] ZIP8 mediates zinc influx into cells - Xenopus tropicalis [Reaction:R-SSC-442387] ZIP8 mediates zinc influx into cells - Sus scrofa [Reaction:R-BTA-442387] ZIP8 mediates zinc influx into cells - Bos taurus [Reaction:R-CFA-442387] ZIP8 mediates zinc influx into cells - Canis familiaris [Reaction:R-RNO-442387] ZIP8 mediates zinc influx into cells - Rattus norvegicus [Reaction:R-MMU-442387] ZIP8 mediates zinc influx into cells - Mus musculus
output	2 × [SimpleEntity:R-ALL-111627] HCO3- [cytosol] [SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-442387
summation	[Summation:442353] The human gene SLC39A8 encodes the zinc transporter ZIP8 (BI...
updateTrackers	[UpdateTracker:9964706] Update Tracker - [Reaction:442387] ZIP8 mediates zinc influx into cells - v94:[modifyText, removeInput, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9964706] Update Tracker - [Reaction:442387] ZIP8 mediates zinc influx into cells - v94:[modifyText, removeInput, removeLiteratureReference, removeOutput]
(precedingEvent)	[Reaction:R-HSA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Reaction:R-HSA-437084] ZnT3 transports zinc into synaptic vesicles [Reaction:R-HSA-435375] ZnT2 facilitates zinc vesicular sequestration [Reaction:R-HSA-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule [Reaction:R-HSA-437139] ZnT8 transports zinc into the Golgi apparatus [Reaction:R-HSA-9820566] ZnT5 transports zinc into the golgi apparatus [Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [NegativePrecedingEvent:9963158] Futile Cycle: ZIP8 mediates zinc influx into cells
(hasEvent)	[Pathway:R-HSA-442380] Zinc influx into cells by the SLC39 gene family

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