Reactome | ZnT5 transports zinc into secretory granules in pancreatic beta cells

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ZnT5 transports zinc into secretory granules in pancreatic beta cells Show undefined attributes

authored	[InstanceEdit:437088] Jassal, Bijay, 2009-09-11
catalystActivity	[CatalystActivity:437131] zinc ion transmembrane transporter activity of SLC30A5 [secretory granule membrane]
category	transition
compartment	[Compartment:1462052] secretory granule lumen [Compartment:70101] cytosol
created	[InstanceEdit:437088] Jassal, Bijay, 2009-09-11
crossReference	[DatabaseIdentifier:12667915] RHEA:29351
dbId	437085
displayName	ZnT5 transports zinc into secretory granules in pancreatic beta cells
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-435368] Zinc efflux and compartmentalization by the SLC30 family - Homo sapiens [Pathway:R-HSA-264876] Insulin processing - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-265160] Insulin secretory granule translocates to cell cortex - Homo sapiens
input	[SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:437091] Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ZnT5 transports zinc into secretory granules in pancreatic beta cells
orthologousEvent	[Reaction:R-SCE-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Saccharomyces cerevisiae [Reaction:R-SPO-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Schizosaccharomyces pombe [Reaction:R-DDI-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Dictyostelium discoideum [Reaction:R-CEL-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Caenorhabditis elegans [Reaction:R-GGA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Gallus gallus [Reaction:R-XTR-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Xenopus tropicalis [Reaction:R-DRE-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Danio rerio [Reaction:R-SSC-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Sus scrofa [Reaction:R-BTA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Bos taurus [Reaction:R-CFA-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Canis familiaris [Reaction:R-RNO-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Rattus norvegicus [Reaction:R-MMU-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Mus musculus
output	[SimpleEntity:R-ALL-216785] Zn2+ [secretory granule lumen]
precedingEvent	[Reaction:R-HSA-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Homo sapiens [Reaction:R-HSA-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Homo sapiens [Reaction:R-HSA-442387] ZIP8 mediates zinc influx into cells - Homo sapiens [Reaction:R-HSA-442345] hZIP10 mediates zinc influx into cells - Homo sapiens [Reaction:R-HSA-442405] hZIP5 mediates zinc uptake by cells - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-437085
summation	[Summation:437076] The human gene SLC30A5 encodes the zinc transporter ZnT5. T...

Referrals

(hasEvent)	[Pathway:R-HSA-264876] Insulin processing [Pathway:R-HSA-435368] Zinc efflux and compartmentalization by the SLC30 family
(precedingEvent)	[BlackBoxEvent:R-HSA-265160] Insulin secretory granule translocates to cell cortex

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