Reactome | ZIP8 mediates zinc influx into cells

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ZIP8 mediates zinc influx into cells Show undefined attributes

catalystActivity	[CatalystActivity:10938335] zinc ion transmembrane transporter activity of SLC39A8-like proteins [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10938337
displayName	ZIP8 mediates zinc influx into cells
eventOf	[Pathway:R-CEL-442380] Zinc influx into cells by the SLC39 gene family - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells - Caenorhabditis elegans [Reaction:R-CEL-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule - Caenorhabditis elegans [Reaction:R-CEL-437139] ZnT8 transports zinc into the Golgi apparatus - Caenorhabditis elegans [Reaction:R-CEL-9820566] ZnT5 transports zinc into the golgi apparatus - Caenorhabditis elegans [Reaction:R-CEL-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-442387] ZIP8 mediates zinc influx into cells - Homo sapiens
input	2 × [SimpleEntity:R-ALL-425425] HCO3- [extracellular region] [SimpleEntity:R-ALL-158417] Zn2+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	ZIP8 mediates zinc influx into cells
output	2 × [SimpleEntity:R-ALL-111627] HCO3- [cytosol] [SimpleEntity:R-ALL-29426] Zn2+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-442387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CEL-437085] ZnT5 transports zinc into secretory granules in pancreatic beta cells [Reaction:R-CEL-437136] SLC30A8 transports Zn2+ from cytosol to secretory granule [Reaction:R-CEL-437139] ZnT8 transports zinc into the Golgi apparatus [Reaction:R-CEL-9820566] ZnT5 transports zinc into the golgi apparatus [Reaction:R-CEL-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
(hasEvent)	[Pathway:R-CEL-442380] Zinc influx into cells by the SLC39 gene family
(inferredTo)	[Reaction:R-HSA-442387] ZIP8 mediates zinc influx into cells

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