Reactome | NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages

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NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages Show undefined attributes

authored	[InstanceEdit:435174] Jassal, Bijay, 2009-09-07
catalystActivity	[CatalystActivity:445828] metal cation:proton antiporter activity of SLC11A1 [late endosome membrane]
category	transition
compartment	[Compartment:172574] late endosome membrane [Compartment:70101] cytosol [Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:435174] Jassal, Bijay, 2009-09-07
crossReference	[DatabaseIdentifier:9957281] RHEA:28841 [DatabaseIdentifier:12667905] RHEA:29579 [DatabaseIdentifier:12667919] RHEA:73063 [DatabaseIdentifier:12667918] RHEA:28839 [DatabaseIdentifier:9957274] RHEA:29441 [DatabaseIdentifier:9957277] RHEA:73065
dbId	435171
displayName	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-6803544] Ion influx/efflux at host-pathogen interface - Homo sapiens [Pathway:R-HSA-425410] Metal ion SLC transporters - Homo sapiens [Pathway:R-HSA-1222556] ROS and RNS production in phagocytes - Homo sapiens
input	[DefinedSet:R-ALL-445829] Divalent metals transported by NRAMP1 [cytosol] [SimpleEntity:R-ALL-1470067] H+ [phagocytic vesicle lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:435365] Isolation and characterization of human Nramp cDNA [LiteratureReference:435173] Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes [LiteratureReference:9957269] Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
orthologousEvent	[Reaction:R-RNO-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Rattus norvegicus [Reaction:R-CFA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Canis familiaris [Reaction:R-BTA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Bos taurus [Reaction:R-SSC-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Sus scrofa [Reaction:R-DRE-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Danio rerio [Reaction:R-XTR-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Xenopus tropicalis [Reaction:R-GGA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Gallus gallus [Reaction:R-DME-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Drosophila melanogaster [Reaction:R-CEL-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Caenorhabditis elegans [Reaction:R-DDI-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Dictyostelium discoideum [Reaction:R-PFA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Plasmodium falciparum [Reaction:R-MMU-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Mus musculus
output	[DefinedSet:R-ALL-445832] Divalent metals transported by NRAMP1 [phagocytic vesicle lumen] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-442317] ZIP6 and ZIP14 mediate zinc influx into cells - Homo sapiens [Reaction:R-HSA-442393] ZIP7 mediates zinc efflux from the endoplasmic reticulum - Homo sapiens [Reaction:R-HSA-442387] ZIP8 mediates zinc influx into cells - Homo sapiens [Reaction:R-HSA-442345] hZIP10 mediates zinc influx into cells - Homo sapiens [Reaction:R-HSA-442405] hZIP5 mediates zinc uptake by cells - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12 [InstanceEdit:9964311] D'Eustachio, Peter, 2025-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-435171
summation	[Summation:435170] Natural resistance-associated macrophage proteins (NRAMPs) r...
updateTrackers	[UpdateTracker:9778756] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v67:[modifyText] [UpdateTracker:9789253] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v38:[add_removeOutput] [UpdateTracker:9783803] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v55:[modifyText] [UpdateTracker:9964758] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v94:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference] [UpdateTracker:9789995] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v36:[add_removeInput, add_removeOutput]

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[UpdateTracker:9778756] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v67:[modifyText]
[UpdateTracker:9789253] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v38:[add_removeOutput]
[UpdateTracker:9783803] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v55:[modifyText]
[UpdateTracker:9964758] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v94:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
[UpdateTracker:9789995] Update Tracker - [Reaction:435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - v36:[add_removeInput, add_removeOutput]

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