ZIP8 mediates zinc influx into cells

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R-HSA-442387
Type
Reaction [transition]
Species
Homo sapiens
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The human gene SLC39A8 encodes the zinc transporter ZIP8 (BIGM103, BCG-induced integral membrane protein in monocyte clone 103 protein). It is highly expressed in the pancreas and localized to the plasma membrane where it mediates the influx of zinc into the cell (Besecker B et al, 2008). The highly homologous mouse ZIP8 have been shown to play important roles in regulating zinc homeostasis and determining sensitivity to cadmium toxicity in mouse testicular endothelium and kidney tissue. It is expected the human transporter plays a similar role (He L et al, 2009). ZIP8 belongs to the LZT subfamily of ZIP transporters.

Literature References
PubMed ID Title Journal Year
19265717 Discovery of ZIP transporters that participate in cadmium damage to testis and kidney

He, L, Wang, B, Hay, EB, Nebert, DW

Toxicol Appl Pharmacol 2009
18390834 The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

Besecker, B, Bao, S, Bohacova, B, Papp, A, Sadee, W, Knoell, DL

Am J Physiol Lung Cell Mol Physiol 2008
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Catalyst Activity
Catalyst Activity
Title
zinc ion transmembrane transporter activity of SLC39A8-like proteins [plasma membrane]
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Activity
Orthologous Events
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Rhea
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