Reactome | ZIP8 mediates zinc influx into cells

ZIP8 mediates zinc influx into cells

Stable Identifier

R-HSA-442387

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The human gene SLC39A8 encodes the zinc transporter ZIP8 (BIGM103, BCG-induced integral membrane protein in monocyte clone 103 protein). SLC39A8 achieves electroneutrality by cotransporting two bicarbonate anions (He et al., 2006). It is highly expressed in the pancreas and localized to the plasma membrane where it mediates the influx of zinc into the cell (Besecker B et al, 2008). The highly homologous mouse ZIP8 have been shown to play important roles in regulating zinc homeostasis and determining sensitivity to cadmium toxicity in mouse testicular endothelium and kidney tissue. It is expected the human transporter plays a similar role (He L et al, 2009). ZIP8 belongs to the LZT subfamily of ZIP transporters.

Literature References

PubMed ID	Title	Journal	Year
18390834	The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia Besecker, B, Bao, S, Bohacova, B, Papp, A, Sadee, W, Knoell, DL	Am J Physiol Lung Cell Mol Physiol	2008
16638970	ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties He, L, Girijashanker, K, Dalton, TP, Reed, J, Li, H, Soleimani, M, Nebert, DW	Mol. Pharmacol.	2006
19265717	Discovery of ZIP transporters that participate in cadmium damage to testis and kidney He, L, Wang, B, Hay, EB, Nebert, DW	Toxicol Appl Pharmacol	2009