VAV1 is a GEF for Rho/Rac family GTPases

Stable Identifier
R-HSA-442273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Vav family members are guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. Vav1 is a GEF for Rac1, Rac2 and RhoG, and possibly RhoA and Cdc42

Literature References
PubMed ID Title Journal Year
18589439 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1

Chrencik, JE, Brooun, A, Zhang, H, Mathews, II, Hura, GL, Foster, SA, Perry, JJ, Streiff, M, Ramage, P, Widmer, H, Bokoch, GM, Tainer, JA, Weckbecker, G, Kuhn, P

J Mol Biol 2008
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR

Nature 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y174-VAV1 [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created
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