Reactome | VAV1 is a GEF for Rho/Rac family GTPases

VAV1 is a GEF for Rho/Rac family GTPases

Stable Identifier

R-HSA-442273

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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VAV1 is a GEF for Rho/Rac family GTPases

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Vav family members are guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. Vav1 is a GEF for Rac1, Rac2 and RhoG, and possibly RhoA and Cdc42

Literature References

PubMed ID	Title	Journal	Year
8990121	Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Ostrom, AA, Bustelo, XR, Gutkind, JS, Crespo, P, Schuebel, KE	Nature	1997
18589439	Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1 Kuhn, P, Tainer, JA, Streiff, M, Zhang, H, Widmer, H, Hura, GL, Chrencik, JE, Perry, JJ, Bokoch, GM, Brooun, A, Ramage, P, Foster, SA, Weckbecker, G, Mathews, II	J Mol Biol	2008