Reactome | VAV1 is a GEF for Rho/Rac family GTPases

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VAV1 is a GEF for Rho/Rac family GTPases Show undefined attributes

catalystActivity	[CatalystActivity:10017072] guanyl-nucleotide exchange factor activity of p-Y174-VAV1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10017080
displayName	VAV1 is a GEF for Rho/Rac family GTPases
eventOf	[Pathway:R-MMU-114604] GPVI-mediated activation cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-114543] VAV1 Rho/Rac effectors:GDP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	VAV1 is a GEF for Rho/Rac family GTPases
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-114539] VAV1 Rho/Rac effectors:GTP [cytosol]
regulatedBy	[NegativeRegulation:10017081] Negative regulation by 'VAV family:PIP2 [plasma membrane]' [PositiveRegulation:10017082] Positive regulation by 'PIP3:VAV1,2,3 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-442273
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-114604] GPVI-mediated activation cascade
(inferredTo)	[Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases

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