Reactome | SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

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SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:435367] Jassal, Bijay, 2009-09-09
catalystActivity	[CatalystActivity:435344] iron ion transmembrane transporter activity of SLC11A2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:435367] Jassal, Bijay, 2009-09-09
crossReference	[DatabaseIdentifier:12667905] RHEA:29579 [DatabaseIdentifier:9957286] RHEA:29581
dbId	435349
diseaseReaction	[FailedReaction:R-HSA-5623558] Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol - Homo sapiens
displayName	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens [Pathway:R-HSA-425410] Metal ion SLC transporters - Homo sapiens
followingEvent	[Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Homo sapiens [Reaction:R-HSA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-435347] Fe2+ [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:435376] Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
negativePrecedingEvent	[NegativePrecedingEvent:9963161] Futile Cycle: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region [NegativePrecedingEvent:9963149] Futile Cycle: SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region
orthologousEvent	[Reaction:R-PFA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Plasmodium falciparum [Reaction:R-DDI-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Dictyostelium discoideum [Reaction:R-CEL-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-71067] Fe2+ [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-917805] CYBRD1:Heme reduces Fe3+ to Fe2+ - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-435349
summation	[Summation:435343] The primary site for absorption of dietary iron is the duode...
updateTrackers	[UpdateTracker:9785647] Update Tracker - [Reaction:435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - v51:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785647] Update Tracker - [Reaction:435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - v51:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5623558] Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-425410] Metal ion SLC transporters [Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages [NegativePrecedingEvent:9963156] Futile Cycle: SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol [Reaction:R-HSA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

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