Reactome | SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region

Schema > Reaction > Entries

SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region Show undefined attributes

authored	[InstanceEdit:442374] Jassal, Bijay, 2009-09-25
catalystActivity	[CatalystActivity:904829] iron ion transmembrane transporter activity of SLC40A1:CP:6Cu2+ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:904828] Jassal, Bijay, 2010-07-05
crossReference	[DatabaseIdentifier:12667548] RHEA:28486 [DatabaseIdentifier:9957289] RHEA:28487
dbId	904830
diseaseReaction	[FailedReaction:R-HSA-5655733] Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region - Homo sapiens
displayName	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens [Pathway:R-HSA-425410] Metal ion SLC transporters - Homo sapiens
input	[SimpleEntity:R-ALL-71067] Fe2+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:904841] Ceruloplasmin in neurodegenerative diseases [LiteratureReference:442331] In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region Ferroportin mediates iron efflux on macrophages
orthologousEvent	[Reaction:R-CEL-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Caenorhabditis elegans [Reaction:R-GGA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Gallus gallus [Reaction:R-XTR-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Xenopus tropicalis [Reaction:R-DRE-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Danio rerio [Reaction:R-SSC-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Sus scrofa [Reaction:R-BTA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Bos taurus [Reaction:R-CFA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Canis familiaris [Reaction:R-RNO-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Rattus norvegicus [Reaction:R-MMU-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-435347] Fe2+ [extracellular region]
precedingEvent	[Reaction:R-HSA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
revised	[InstanceEdit:5621428] Jassal, Bijay, 2014-08-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-904830
summation	[Summation:904833] SLC40A1 (MTP1 aka ferroportin or IREG1) is highly expressed ...
updateTrackers	[UpdateTracker:9786023] Update Tracker - [Reaction:904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - v50:[modifyText] [UpdateTracker:9785183] Update Tracker - [Reaction:904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - v52:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786023] Update Tracker - [Reaction:904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - v50:[modifyText] [UpdateTracker:9785183] Update Tracker - [Reaction:904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - v52:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5655733] Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-425410] Metal ion SLC transporters [Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)	[NegativePrecedingEvent:9963161] Futile Cycle: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region