Reactome | SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

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SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10853123] iron ion transmembrane transporter activity of SLC11A2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10853125
displayName	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
eventOf	[Pathway:R-DME-917937] Iron uptake and transport - Drosophila melanogaster [Pathway:R-DME-425410] Metal ion SLC transporters - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-435347] Fe2+ [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
output	[SimpleEntity:R-ALL-71067] Fe2+ [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-DME-917805] CYBRD1:Heme reduces Fe3+ to Fe2+ - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-435349
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-425410] Metal ion SLC transporters [Pathway:R-DME-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-DME-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
(inferredTo)	[Reaction:R-HSA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol

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