Reactome | Metal ion SLC transporters

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Metal ion SLC transporters Show undefined attributes

authored	[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
created	[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
dbId	425410
diseasePathways	[Pathway:R-HSA-5619088] Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) - Homo sapiens [Pathway:R-HSA-5619092] Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) - Homo sapiens [Pathway:R-HSA-5619055] Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) - Homo sapiens [Pathway:R-HSA-5619052] Defective SLC9A9 causes autism 16 (AUTS16) - Homo sapiens [Pathway:R-HSA-5619036] Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) - Homo sapiens
displayName	Metal ion SLC transporters
edited	[InstanceEdit:425388] Jassal, Bijay, 2009-06-04
eventOf	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18822] metal ion transport
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-425986] Sodium/Proton exchangers - Homo sapiens [Pathway:R-HSA-425561] Sodium/Calcium exchangers - Homo sapiens [Pathway:R-HSA-435354] Zinc transporters - Homo sapiens [Reaction:R-HSA-435171] NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages - Homo sapiens [Reaction:R-HSA-435349] SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-904830] SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-437300] SLC31A1 transports Cu1+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-442661] SLC41A1,2 transport Mg2+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8959798] SLC30A10 transports Mn2+ from cytosol to extracellular region - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-12-07
literatureReference	[LiteratureReference:434654] Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities [LiteratureReference:434662] Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters [LiteratureReference:434186] The NRAMP family of metal-ion transporters [LiteratureReference:434188] Zinc transporters and the cellular trafficking of zinc [LiteratureReference:434660] Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload [LiteratureReference:434168] The SLC39 family of metal ion transporters [LiteratureReference:434173] Magnesium transporters: properties, regulation and structure [LiteratureReference:434165] Zinc fluxes and zinc transporter genes in chronic diseases [LiteratureReference:434184] SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1 [LiteratureReference:434174] The copper transporter (Ctr) family of Cu+ uptake systems [LiteratureReference:434176] The SLC31 (Ctr) copper transporter family [LiteratureReference:434175] The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1) [LiteratureReference:427985] Analysis and update of the human solute carrier (SLC) gene superfamily [LiteratureReference:425575] The sodium/calcium exchanger family-SLC8 [LiteratureReference:426016] Diversity of the mammalian sodium/proton exchanger SLC9 gene family [LiteratureReference:433767] Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Metal ion SLC transporters
orthologousEvent	[Pathway:R-MMU-425410] Metal ion SLC transporters - Mus musculus [Pathway:R-RNO-425410] Metal ion SLC transporters - Rattus norvegicus [Pathway:R-CFA-425410] Metal ion SLC transporters - Canis familiaris [Pathway:R-BTA-425410] Metal ion SLC transporters - Bos taurus [Pathway:R-SSC-425410] Metal ion SLC transporters - Sus scrofa [Pathway:R-DRE-425410] Metal ion SLC transporters - Danio rerio [Pathway:R-XTR-425410] Metal ion SLC transporters - Xenopus tropicalis [Pathway:R-GGA-425410] Metal ion SLC transporters - Gallus gallus [Pathway:R-DME-425410] Metal ion SLC transporters - Drosophila melanogaster [Pathway:R-CEL-425410] Metal ion SLC transporters - Caenorhabditis elegans [Pathway:R-DDI-425410] Metal ion SLC transporters - Dictyostelium discoideum [Pathway:R-SPO-425410] Metal ion SLC transporters - Schizosaccharomyces pombe [Pathway:R-SCE-425410] Metal ion SLC transporters - Saccharomyces cerevisiae [Pathway:R-PFA-425410] Metal ion SLC transporters - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-425410
summation	[Summation:434656] Six SLC gene families encode proteins which mediate transpor...
updateTrackers	[UpdateTracker:9789172] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v38:[updateContainedRLE] [UpdateTracker:9781567] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v60:[addHasEvent] [UpdateTracker:9846832] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v83:[updateContainedPathway] [UpdateTracker:9785301] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v52:[updateContainedRLE] [UpdateTracker:9790300] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v34:[addHasEvent, updateContainedRLE] [UpdateTracker:9789764] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v37:[updateContainedPathway] [UpdateTracker:9780320] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v63:[updateContainedRLE] [UpdateTracker:9785566] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v51:[updateContainedRLE] [UpdateTracker:9786421] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v49:[updateContainedPathway] [UpdateTracker:9784037] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v55:[updateContainedRLE] [UpdateTracker:9786282] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v50:[updateContainedRLE] [UpdateTracker:9778709] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v67:[updateContainedRLE] [UpdateTracker:9789892] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v36:[updateContainedRLE] [UpdateTracker:9964696] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v94:[removeHasEvent, removeLiteratureReference]

Referrals

(hasEvent)	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport
(normalPathway)	[Pathway:R-HSA-5619088] Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) [Pathway:R-HSA-5619092] Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) [Pathway:R-HSA-5619055] Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) [Pathway:R-HSA-5619052] Defective SLC9A9 causes autism 16 (AUTS16) [Pathway:R-HSA-5619036] Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
(updatedInstance)	[UpdateTracker:9789172] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v38:[updateContainedRLE] [UpdateTracker:9781567] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v60:[addHasEvent] [UpdateTracker:9846832] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v83:[updateContainedPathway] [UpdateTracker:9785301] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v52:[updateContainedRLE] [UpdateTracker:9790300] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v34:[addHasEvent, updateContainedRLE] [UpdateTracker:9789764] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v37:[updateContainedPathway] [UpdateTracker:9780320] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v63:[updateContainedRLE] [UpdateTracker:9785566] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v51:[updateContainedRLE] [UpdateTracker:9786421] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v49:[updateContainedPathway] [UpdateTracker:9784037] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v55:[updateContainedRLE] [UpdateTracker:9786282] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v50:[updateContainedRLE] [UpdateTracker:9778709] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v67:[updateContainedRLE] [UpdateTracker:9789892] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v36:[updateContainedRLE] [UpdateTracker:9964696] Update Tracker - [Pathway:425410] Metal ion SLC transporters - v94:[removeHasEvent, removeLiteratureReference]

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